HSK0935
CAS No. : 1638851-44-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $440 | In-stock |
| 10mg | $705 | In-stock |
| 25mg | $1480 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-101782 |
| M.Wt: | 436.88 |
| Formula: | C22H25ClO7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities[1]. IC50 & Target: IC50: 1.3 nM (SGLT2)[1] In Vitro: HSK0935 (Compound 31) demonstrates excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold[1]. In Vivo: HSK0935 treatment (1, 3, and 10 mg/kg) shows robust urinary glucose excretion in Sprague Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys[1].
HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs[1].
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