DETQ
CAS No. : 1638667-81-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $480 | Get quote |
| 5mg | $1200 | Get quote |
| 10mg | $1950 | Get quote |
| 25mg | $4050 | Get quote |
| 50mg | $6500 | Get quote |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-115553 |
| M.Wt: | 422.34 |
| Formula: | C22H25Cl2NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC50 of 5.8 nM and a Kb of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor[1]. In Vivo:DETQ (10 mg/kg; i.p.; once) ameliorates subchronic Phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice[2].
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