TH287 (hydrochloride)
CAS No. : 1638211-05-8
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| Cat. No. : | HY-16965A |
| M.Wt: | 305.59 |
| Formula: | C11H11Cl3N4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research[1].
IC50 & Target: IC50: 0.8 nM (MTH1)[1]
In Vitro: TH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells[1].
In Vivo: TH287 (5 mg/kg; i.p.) exhibits Cmax of 0.82 μM and tmax of 0.5 h in mice[2].
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