Auristatin F
CAS No. : 163768-50-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $96 | In-stock |
| 50mg | $135 | In-stock |
| 100mg | $190 | In-stock |
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| Cat. No. : | HY-15583 |
| M.Wt: | 745.99 |
| Formula: | C40H67N5O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Auristatin F is a potent cytotoxin in antibo-conjugated drugs and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) [1][2]. IC50 & Target:Microtubule[1] In Vitro:Auristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates[1]. In Vivo:Auristatin F (5 mg/kg; i.v.; male Sprague-Dawley rats) has Cmax of 8276.76 ng/mL. The AUClast is 65661.30 min*ng/mL, and the clearance (CL) is 77.33 mL/min/kg, which is above the hepatic blood flow in the rat[2].
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