Cangrelor
CAS No. : 163706-06-7
(Synonyms: AR-C69931MX)
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| Cat. No. : | HY-19638 |
| M.Wt: | 776.36 |
| Formula: | C17H25Cl2F3N5O12P3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist[1][2]. IC50 & Target: P2Y12, GPR17[1][2] In Vitro: Cangrelor tetrasodium has pKb of 8.6-9.2 for hP2Y12 receptor[3]. In Vivo: Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[2].
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