MAZ51
CAS No. : 163655-37-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $96 | In-stock |
| 10mg | $155 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-116624 |
| M.Wt: | 314.38 |
| Formula: | C21H18N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C) |
MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity[1][2].
In Vitro: MAZ51 (2.5-10 μM; 24 hours) blocks proliferation and induces apoptosis in a wide variety of tumor cells[2].
MAZ51 (0.5-50 μM; 25 minutes) has no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ in A431 cells, HEK-293 cells, and PAE cells, respectively[2].
In Vivo: MAZ51 (8 mg/kg; i.p.; daily for 15 day) significantly suppresses the growth of MT450 tumors[2].
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