EEDQ
CAS No. : 16357-59-8
(Synonyms: EEDQ)
| Size | Price | Stock |
|---|---|---|
| 25g | $11 | In-stock |
| 100g | $34 | In-stock |
| 250g | $58 | In-stock |
| 500g | $108 | In-stock |
| 1000g | $178 | In-stock |
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| Cat. No. : | HY-Y1191 |
| M.Wt: | 247.29 |
| Formula: | C14H17NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM). EEDQ inhibits contralateral rotation behavior[1][2][3][4][5].
In Vitro:EEDQ (1 mM; 30 min) has no effect on glycogen phosphorylase activity or cell viability of hepatocytes[1].
EEDQ (10-300 μM) concentration-dependently decreases [3H]β-CIT binding to dopamine transporters (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM)[3].
In Vivo:EEDQ (25-50 mg/kg; i.p.) dose-dependently inhibits Apomorphine (HY-12723), SKF 38393 (HY-12520A), and Quinpirole (HY-B1752)-induced contralateral rotational behavior in mice with unilateral striatal 6-hydroxydopamine lesions, and the behavior recovers at 48 h[4].
EEDQ (7.5 mg/kg; i.p.) does not disrupt NPA-induced stereotyped sniffing and locomotor activity in 11-day-old and 17-day-old Sprague-Dawley rat pups[5].
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