YM440
CAS No. : 163300-58-1
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| Cat. No. : | HY-117597 |
| M.Wt: | 468.42 |
| Formula: | C22H20N4O8 |
| Purity: | >98 % |
| Solubility: |
YM440 is an orally active oxadiazolidinedione analog. YM440 ameliorates hyperglycemia without changing PPARy activity, adipocyte differentiation, or fat weight. YM440 is used in the study for non-insulin-dependent diabetes mellitus (NIDDM)[1].
In Vivo:YM440 (100 mg/kg, orally, daily for 28 days, db/db mice) increases hepatic glucokinase expression but not adipose tissue FABP and UCP1 expression, indicating a tissue selective expression of PPARγ-related genes[2].
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