Folinic acid (disodium)
CAS No. : 163254-40-8
(Synonyms: Leucovorin (disodium))
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| Cat. No. : | HY-17556A |
| M.Wt: | 517.40 |
| Formula: | C20H21N7Na2O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3]. In Vitro: Folinic acid disodium (5, 50 µg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h[1]. In Vivo: Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].
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