PF-06446846 (hydrochloride)
CAS No. : 1632250-50-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $255 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120088A |
| M.Wt: | 470.35 |
| Formula: | C22H21Cl2N7O |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34[1]. IC50 & Target: PCSK9[1] In Vitro: PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM[1]. In Vivo: PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels[1].
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Inquiry Information- Product Name:
- PF-06446846 (hydrochloride)
- Cat. No.:
- HY-120088A
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