PF-06446846
CAS No. : 1632250-49-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $255 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-120088 |
| M.Wt: | 433.89 |
| Formula: | C22H20ClN7O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region[1]. In Vitro: PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM[1]. PF-06446846 inhibits PCSK9(1–35)-luciferase expression with an IC50 of 2 μM[1]. PF-06446846 (Compound 7f) shows rat bone marrow and human CD34+ toxicity[2]. In Vivo: PF-06446846 reduces circulating PCSK9 and total plasma cholesterol levels in vivo without obvious toxicity[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- PF-06446846
- Cat. No.:
- HY-120088
- Quantity:
Your information is safe with us.