BAR501
CAS No. : 1632118-69-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $128 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $570 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-101274 |
| M.Wt: | 406.64 |
| Formula: | C26H46O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;Ethanol : 120 mg/mL (ultrasonic) |
BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM. IC50 & Target:EC50: 1 μM (GPBAR1)[1] In Vitro:BAR501 is a selective GPBAR1 agonist devoid of FXR agonistic activity. It effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with an EC50 of 1 μM. Exposure of GLUTAg cells to BAR501 (10 μM) increases the expression of GLP-1 mRNA by 2.5 folds[1]. In Vivo:Pretreating rats for 6 days with BAR501, 15 mg/kg, reduces basal portal pressure and blunts the vasoconstriction activity of norepinephrine. Pretreatment with BAR501 attenuates the hepatic vasomotor activity induced by shear stress and methoxamine. Administration of BAR501 exerts a direct vasodilatory activity in the CCl4 model. Treating mice with BAR501 at the dose of 15 mg/Kg reduces portal pressure and AST plasma levels. BAR501 attenuates endothelial dysfunction by regulating CSE expression/activity[1].
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