(S,R,S)-AHPC (TFA)
CAS No. : 1631137-51-3
(Synonyms: VH032-NH2 (TFA); VHL ligand 1 (TFA))
| Size | Price | Stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-110402 |
| M.Wt: | 544.59 |
| Formula: | C24H31F3N4O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].
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