(R)-DNMDP
CAS No. : 1630760-60-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $420 | In-stock |
| 10mg | $700 | In-stock |
| 50mg | $2000 | In-stock |
| 100mg | $3000 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-122751 |
| M.Wt: | 304.34 |
| Formula: | C15H20N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. (R)-DNMDP has a 500-fold lower EC50 compared to the (S)-enantiomer in HeLa cell line[1][2].
In Vitro: (R)-DNMDP (0.1 pM-1 mM; for 48 hours) has a 500-fold lower EC50 compared to the (S)-enantiomer in HeLa cell line[1].
(S)-DNMDP has non-cytotoxic. Binding of PDE3A to the linker analogue is blocked by both trequinsin and (R)-DNMDP, but not by the (S)-DNMDP[1].
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