Fezolinetant
CAS No. : 1629229-37-3
(Synonyms: ESN-364)
| Size | Price | Stock |
|---|---|---|
| 1mg | $90 | In-stock |
| 5mg | $185 | In-stock |
| 10mg | $295 | In-stock |
| 25mg | $590 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1450 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19632 |
| M.Wt: | 358.39 |
| Formula: | C16H15FN6OS |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes. In Vivo:Fezolinetant (ESN364, 1 mg/kg, iv bolus) reversibly inhibits the regular, pulsatile secretion of LH in the ovarectomized ewe. ESN364 represses the pulse pattern of LH in all treated animals. ESN364 (5 mg/kg, p.o.) lowers plasma LH, but not FSH, in the castrated monkey. ESN364 (10, 25, 50 mg/kg, orally) also blocks the LH surge and decreases ovarian hormone levels throughout the menstrual cycle in monkeys[1].
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