GNE-131
CAS No. : 1629063-81-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $340 | In-stock |
| 10mg | $490 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-112279 |
| M.Wt: | 442.57 |
| Formula: | C23H30N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. IC50 & Target: IC50: 3 nM (hNaV1.7)[1]. In Vitro: GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability[1]. In Vivo: GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain[1].
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