Ibiglustat (L-Malic acid)
CAS No. : 1629063-78-0
(Synonyms: Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid))
| Size | Price | Stock |
|---|---|---|
| 2mg | $100 | In-stock |
| 5mg | $190 | In-stock |
| 10mg | $340 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-16743A |
| M.Wt: | 523.57 |
| Formula: | C24H30FN3O7S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease[1][2]. IC50 & Target: Glucosylceramide synthase[1]. In Vitro: Ibiglustat (SAR402671) (1 μM, 15 days) L-Malic acid treated Fabry disease (FD) cells are close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat L-Malic acid can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes[4].
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