IDH-305
CAS No. : 1628805-46-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $680 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-104036 |
| M.Wt: | 490.45 |
| Formula: | C23H22F4N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 150 mg/mL |
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50= 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (IDH1WT))[1][2]. IC50 & Target: IC50: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (IDH1WT)[1] In Vitro: IDH-305 inhibits HCT116-IDH1R132H+/- cells with an IC50 of 24 nM[1]. In Vivo: IDH-305 (30-300 mg/kg; p.o.; twice daily for 21 days) inhibits 2-HG production and 2-HG-dependent tumor growth of an IDH1 mutant PDX melanoma model[1].
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- IDH-305
- Cat. No.:
- HY-104036
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