BG47
CAS No. : 1628784-54-2
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| Cat. No. : | HY-117583A |
| M.Wt: | 442.53 |
| Formula: | C25H22N4O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research[1].
In Vitro: BG47 (10 μM, 16 hours) elevates H3K9 acetylation only in the presence of light and also significantly upregulates the expression of haploinsufficiency of progranulin (PGRN) only in the presence of light (25 ms on/75 ms off) in human neural progenitor cells (NPCs)[1].
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