Polygalaxanthone III
CAS No. : 162857-78-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $34 | In-stock |
| 5mg | $68 | In-stock |
| 10mg | $109 | In-stock |
| 20mg | $175 | In-stock |
| 50mg | $315 | In-stock |
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| Cat. No. : | HY-N1407 |
| M.Wt: | 568.48 |
| Formula: | C25H28O15 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Polygalaxanthone III is a representative xanthone component of Polygala tenuifolia. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, with an IC50 of 50.56 μM. Polygalaxanthone III repairs skin damage induced by M. furfur via activating STAT3 phosphorylation and exerts anti-inflammatory effects. Polygalaxanthone III can be used for research on M. furfur-related skin damage[1].
In Vitro:Polygalaxanthone III (0.5-2.0 mM; 24 h post-stimulation/6 h pre-incubation) significantly reduces lipid droplet formation in M. furfur-stimulated HaCaT cells, but shows no such effect when administered prior to stimulation[1].
Polygalaxanthone III (0.13-1.0 mM) exerts no significant inhibitory effect on the in vitro growth of M. furfur[1].
In Vivo:Polygalaxanthone III (accounting for 1-2% (w/w); administered topically; for 12 days) significantly accelerates wound healing, reduces inflammation and repairs skin structure in M. furfur-induced skin injury models of C57BL/6 mice by activating STAT3 phosphorylation[1].
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