GSK467
CAS No. : 1628332-52-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $185 | In-stock |
| 10mg | $278 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $800 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-116761 |
| M.Wt: | 319.32 |
| Formula: | C17H13N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic) |
GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members[1][2].
IC50 & Target: Ki: 10 nM (KDM5B)[1]
In Vitro: GSK467 (0-100 μM; 6 days) shows antiproliferative effect against human multiple myeloma tumor cells[1].
GSK467 is located in the 2-OG-binding pocket[2].
GSK467 inhibits spheroid formation, colony formation, invasion and migration of HCC cells[3].
In Vivo: GSK-467 can inhibit the proliferation and growth of HCC tumor cells by promoting the expression of miR-448 and inhibiting the YTHDF3/ITGA6 pathway in female BALB/c nude mice[3].
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