MI-136
CAS No. : 1628316-74-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $116 | In-stock |
| 10mg | $198 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $960 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19319 |
| M.Wt: | 470.51 |
| Formula: | C23H21F3N6S |
| Purity: | >98 % |
| Solubility: | DMSO : 110 mg/mL (ultrasonic) |
MI-136 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors[1][2].
In Vitro: MI-136 (0-20) exhibits IC50values of 5.59 μM, 7.15 μM, 5.37 μM and 19.76 μM in LNCaP, VCaP, 22rv1 and PNT2 cells[2].
In Vivo: MI-136 exhibits T1/2 of 3.1 h after po administration[1].
MI-136 (40 mg/kg, ip) leads to a significant decrease in the growth of castration-resistant VCaP tumors[2].
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