ML380
CAS No. : 1627138-52-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12439 |
| M.Wt: | 494.53 |
| Formula: | C23H25F3N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
ML380 is a potent, subtype-selective, and brain-penetrant positive allosteric modulator (PAM) of M5 mAChR, with EC50s of 190 and 610 nM for human and rat M5, respectively. ML380 exhibits moderate selectivity versus the M1 and M3 mAChR subtypes. ML380 could increase the affinity of ACh for the M5 mAChR[1][2][3].
IC50 & Target: IC50: 190 nM (hM5), 610 nM (rM5)[1]
In Vitro: ML380 (0.01 nM-100 μM) robustly stimulates inositol phosphate (IP) accumulation and Ca2+ mobilization in CHO-hM5 cells, with pEC50s of 5.33 and 5.71, respectively[2].
ML380 (0.01-30 μM) increases the ACh-stimulated IP accumulation and Ca2+ mobilization in CHO-hM5 cells[2].
In Vivo: ML380 (1 mg/kg; i.v.) displays high clearance (66 mL/min/kg), a moderate volume of distribution (1.6 L/kg), and a short half-life (t1/2, 22 min) in rats[1].
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