JG-231
CAS No. : 1627126-59-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $215 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $670 | In-stock |
| 100mg | $940 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-124611 |
| M.Wt: | 619.47 |
| Formula: | C22H18BrCl2N3OS4 |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic) |
JG-231 is an allosteric inhibitor of heat shock protein 70 (Hsp70). JG - 231 inhibits the binding of Hsp70 and BAG family proteins, including inhibition of Hsp70 and BAG1 with a Ki of 0.11 μM. JG-231 inhibits proliferation of tumor cells and induces apoptosis. JG-231 has antitumor activity[1][2].
In Vitro:JG-231 (0.31-5 μM; 4-10 days) inhibits cell ball growth in 3D cultured TT and MZ-CRC-1 cells in a dose- and time-dependent manner[1].
JG-231 (0-10 μM; 12-24 h) disrupts the interaction between Hsp70 and BAG3, affects the signaling pathway related to Hsp70, and induces cell apoptosis in MCF-7 cells[2].
In Vivo:JG-231 (4 mg/kg; intraperitoneal injection; three times a week for 4 weeks) has an antitumor effect in a mouse model of breast cancer xenotransplantation[2].
Pharmacokinetic Analysis in Mice[1]
| Route | Dose (mg/kg) | Cmax (nM) | Tmax (h) | t1/2 (h) | AUC0-∞ (nM·h) |
| i.p. | 5 | 159 | 2 | 21.6 | 3401 |