UK-157147
CAS No. : 162704-20-3
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| Cat. No. : | HY-100319 |
| M.Wt: | 472.51 |
| Formula: | C23H24N2O7S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM. IC50 & Target: Km: 105 μM (UGT1A1)[1] In Vitro: Glucuronidation is an important pathway for human drug metabolism. Four cloned and expressed human UDP-glucuronosyltransferases (UGT1A1, UGT1A6, UGT1A9, and UGT2B15) are used to screen a series of three potential drug substrates differing only in position of the phenol moiety. The para phenol UK-157147 (UK-157,147) is found to be a substrate for UGT1A1 with a Km value of 105 μM[1].
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