6-Deoxyjacareubin

6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)^[1]. In Vitro: 6-deoxyjacareubin inhibits cytotoxicity induced by sealed chamber hypoxia (1 % O₂) and chemically induced hypoxia (CoCl₂) in HEK293T cells and other types of cell lines such as HT1080 (human sarcoma cell line), Neuro2a (mouse neuroblastoma cell line), and MO3.13 (human oligodendrocytic cell line)^[1]. In Vivo: 6-Deoxyjacareubin (5 mg/kg, i.p., every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice^[1].