ML381
CAS No. : 1623481-80-0
(Synonyms: VU0488130)
| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $950 | In-stock |
| 50mg | $1500 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-101839 |
| M.Wt: | 379.41 |
| Formula: | C21H21N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies[1][2]. IC50 & Target:IC50: 450 nM (mAChR M5)[1]. In Vivo:ML381 (0.2 mg/kg; i.v.; single) possesses an overall acceptable DMPK profile for pharmacodynamic studies in rat, with the exception of poor metabolic stability and a potential for amide hydrolysis in plasma; as such, ML381 is best suited to use as an in vitro/electrophysiological probe[1].
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