Neoseptin 3
CAS No. : 1622863-21-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $105 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $340 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $860 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-U00435 |
| M.Wt: | 474.59 |
| Formula: | C29H34N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC50 of 18.5 μM. IC50 & Target: EC50: 18.5 μM (mTLR4/MD-2) [1] In Vitro: Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC50 of 18.5 μM. Neoseptin-3 induces TNFα production by macrophages in a concentration-dependent manner. Neoseptin-3 induces phosphorylation of IκB kinases α (IKKα), IKKβ, p38, c-Jun N-terminal kinase (JNK), and ERK, and degradation of IκBα, consistent with activation of MAPK and canonical NF-κB signaling. TANK-binding kinase 1 (TBK1) and IRF3 phosphorylation also increase in response to Neoseptin-3[1].
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