CI-1020
CAS No. : 162256-50-0
(Synonyms: PD156707)
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| Cat. No. : | HY-103459 |
| M.Wt: | 506.50 |
| Formula: | C28H26O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ETA) with an IC50 value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration[1][2][3].
In Vitro:CI-1020 (1 μM, 28 days) blocks intimal hyperplasia in human saphenous veins completely in organ culture [1].
CI-1020 (1 μM, 14 days) is not toxic to the tissue[1].
In Vivo:CI-1020 (30 mg/kg, p.o.) represents full inhibition of the ET-A and has no significant effect on basal blood pressure in normotensive rats[2].
CI-1020 (40 mg/kg, p.o.) attenuates established pulmonary hypertension in rats previously exposed to chronic hypoxia[4].
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