BMS-189664
CAS No. : 162166-80-5
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| Cat. No. : | HY-19219 |
| M.Wt: | 478.61 |
| Formula: | C22H34N6O4S |
| Purity: | >98 % |
| Solubility: |
BMS-189664 is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 can be used for arterial and venous thrombosis research[1].
In Vivo:BMS-189664 is efficacious at protecting mice from thrombin-induced lethality[1].
BMS-189664 (0.2 mg/kg, iv) inhibits arterial thrombosis in cynomolgus monkey models[1].
BMS-189664 (infused at 9, 25, and 100 mg/kg/min for 1 h to achieve 0.5, 2, and 6 mg/kg) inhibits venous thrombosis in cynomolgus monkey models[1].
The oral bioavailability of BMS-189664 based on the dose-normalized AUCs after oral and iv dosing was 15 and 17% in dogs and monkeys, respectively[1].
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