RWJ 50271
CAS No. : 162112-37-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $970 | In-stock |
| 50mg | $1300 | In-stock |
| 100mg | $1700 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110086 |
| M.Wt: | 410.41 |
| Formula: | C18H17F3N4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion[1].
IC50 & Target: IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells)[1]
In Vitro: RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1[1].
RWJ 50271 inhibits both human and murine NK activity (IC50=5.0 μM) in an LFA-1/ICAM-1-dependent natural killer [NK] cytotoxicity assay[1].
RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X or VLA-4/VCAM-1-mediated cell adhesion up to 20 μM concentrations[1].
RWJ 50271 does not alter the LFA-1 expression levels on HL60 cells[1].
RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1[1].
RWJ 50271 does not exhibit any toxic activity up to 100 μM concentrations[1].
In Vivo: RWJ 50271 (50 mg/kg; p.o.) is effective in animal model of inflammation[1].
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