DLK-IN-1
CAS No. : 1620574-24-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $550 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1750 | In-stock |
| 50mg | $2750 | In-stock |
| 100mg | $3950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114331 |
| M.Wt: | 423.43 |
| Formula: | C20H24F3N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
DLK-IN-1 (Compound 14) is an orally active, blood-brain barrier-penetrable and selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a Ki value of 3 nM. DLK-IN-1 inhibits Flt3, PAK4, STK33 and TrkA. DLK-IN-1 reduces p-c-Jun. DLK-IN-1 can be used in Alzheimer's disease research[1].
IC50 & Target:Ki: 3 nM (DLK)[1].
In Vitro:DLK-IN-1 can protect axons in a dose-dependent manner, with an EC50 of 0.574 μM[1].
DLK-IN-1 (1 μM) inhibits kinases such as Flt3, PAK4, STK33, and TrkA by ≥50%[1].
In Vivo:DLK-IN-1 (15-50 mg/kg; p.o.) can significantly reduce the phosphorylation level of c-Jun in the PS2APP mouse model of Alzheimer's disease[1].
DLK-IN-1 (25-75 mg/kg; 7 days) is well-tolerated in Sprague-Dawley rats[1].
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