GNE-8505
CAS No. : 1620573-48-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $300 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $950 | In-stock |
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| Cat. No. : | HY-114332 |
| M.Wt: | 419.44 |
| Formula: | C21H24F3N5O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GNE-8505 is an orally active, blood-brain barrier-permeable selective dual leucine zipper kinase (DLK) inhibitor. GNE-8505 inhibits the DLK/JNK pathway, reduces stress-induced c-Jun phosphorylation levels, decreases neuronal death and suppresses axonal degeneration. GNE-8505 reduces phosphorylated c-Jun levels in the retina, spinal cord and brain tissues of mice. GNE-8505 is applicable to research related to Alzheimer's disease and amyotrophic lateral sclerosis (ALS)[1].
In Vivo:GNE-8505 (3-18 mg/kg; p.o.; single administration) rapidly and dose-dependently reduces injury-induced phosphorylated c-Jun levels in the retina of mice, with an in vivo IC50 of 0.98 μM[2].
Single administration of GNE-8505 (35 mg/kg) significantly reduces the number of phosphorylated c-Jun-positive cells in the spinal cord of SOD1G93A ALS mice at the middle stage of the disease[2].
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