UNC0379 (TFA)
CAS No. : 1620401-83-3
| Size | Price | Stock |
|---|---|---|
| 2mg | $80 | In-stock |
| 5mg | $120 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-12335A |
| M.Wt: | 527.58 |
| Formula: | C25H36F3N5O4 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 TFA can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma[1][2][3].
IC50 & Target: SETD8 (KMT5A)[1]
In Vitro: UNC0379 TFA (1-10 μM, 9 days) inhibits HGSOC cells proliferation[2].
UNC0379 TFA (10 μM, 96 h) increases in the proportion of sub-G1 phase cells in HGSOC cells[2].
UNC0379 TFA (10 μM, 48 h) induces myofibroblast de-differentiation and inhibits additional fibroblast to myofibroblast differentiation[3].
In Vivo: UNC0379 TFA (intratracheal administration, 1 mg/kg/day, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse[3].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- UNC0379 (TFA)
- Cat. No.:
- HY-12335A
- Quantity:
Your information is safe with us.