UNC0379
CAS No. : 1620401-82-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $25 | In-stock |
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12335 |
| M.Wt: | 413.56 |
| Formula: | C23H35N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma[1][2][3].
IC50 & Target: SETD8 (KMT5A)[1]
In Vitro: UNC0379 (1-10 μM, 9 days) inhibits HGSOC cells proliferation[2].
UNC0379 (10 μM, 96 h) increases in the proportion of sub-G1 phase cells in HGSOC cells[2].
UNC0379 (10 μM, 48 h) induces myofibroblast de-differentiation and inhibits additional fibroblast to myofibroblast differentiation[3].
In Vivo: UNC0379 (intratracheal administration, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse[3].
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