WJ35435
CAS No. : 1620054-84-3
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| Cat. No. : | HY-117688 |
| M.Wt: | 351.40 |
| Formula: | C20H21N3O3 |
| Purity: | >98 % |
| Solubility: |
WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer[1].
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