Esomeprazole magnesium
CAS No. : 161973-10-0
(Synonyms: (S)-Omeprazole magnesium; (-)-Omeprazole magnesium)
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| Cat. No. : | HY-B1446 |
| M.Wt: | 713.12 |
| Formula: | C34H36MgN6O6S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL;H2O : 3 mg/mL (ultrasonic) |
Esomeprazole magnesium ((S)-Omeprazole magnesium) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium has the potential for upper intestinal disorders and gastroesophageal reflux disease research[1][2]. Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases[4]. IC50 & Target:H+, K+-ATPase[1] In Vitro: Esomeprazole magnesium is an inhibitor of H+, K+-ATPase[1].Esomeprazole magnesium is develped from Esomeprazole strontium tetrahydrate (EST). EST contains esomeprazole, the S-enantiomer of omeprazole a salt-exchanged version of Esomeprazole magnesium trihydrate[3]. In Vivo: Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity[1].
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