D-520
CAS No. : 1619269-47-4
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| Cat. No. : | HY-120156 |
| M.Wt: | 501.66 |
| Formula: | C31H39N3O3 |
| Purity: | >98 % |
| Solubility: |
D-520 is a potent and brain-penetrant dopamine D2/D3 agonist (D2 EC50 = 4.73 nM, Ki = 41.8 nM; D3 EC50 = 2.18 nM, Ki = 0.35 nM). D-520 inhibits the formation of Aβ aggregates in vitro and promotes the disaggregation of both alpha-synuclein (α-syn) and Aβ aggregates. D-520 exhibits efficacious activity in animal models of Parkinson’s disease (PD). D-520 can be used for PD and PD with dementia (PDD) research[1][2]. In Vitro:D-520 (0.01-30 μM, 24 h) exhibits dose-dependent neuroprotective effects against 6-hydroxydopamine (6-OHDA) (HY-B1081)-induced toxicity in MN9D dopaminergic cells[2].
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