Benzamil (hydrochloride)
CAS No. : 161804-20-2
(Synonyms: Benzylamiloride (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $79 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $260 | In-stock |
| 100mg | $460 | In-stock |
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| Cat. No. : | HY-B1546A |
| M.Wt: | 356.21 |
| Formula: | C13H15Cl2N7O |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : ≥ 100 mg/mL |
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3]. In Vitro: Benzamil hydrochloride (Benzylamiloride hydrochloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels[4]. In Vivo: Benzamil hydrochloride (Benzylamiloride hydrochloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].
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