Amentoflavone

Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase^[1][2][3][4]. In Vitro: Amentoflavone (1-60 µM) inhibits the production of nitric oxide in a concentration-dependent manner in RAW 264.7 cells^[2].
Amentoflavone (50-200 µM) inhibits the viability of U-87 MG cells with IC₅₀ value of 100 µM at 48 h^[3].
Amentoflavone (0, 50, 100 µM; 48 h) induces apoptosis and cell cycle arrest at sub-G1 phase^[3].
Amentoflavone (0, 50, 100 µM; 48 h) inhibits NF-ĸB activation and decreases the expression of MCL1 and C-FLIP protein in U-87 MG cells^[3].
Amentoflavone (0-32 µg/ml) shows antibacterial activity with MICs of 8, 4, 32, 8, 16, 8 µg/ml for E. faecium ATCC 19434, S. aureus ATCC 25923, S. mutans ATCC 3065, E. coli O-157 ATCC 25922, E. coli ATCC 43895, P. aeruginosa ATCC 27853, respectively^[4]. In Vivo: Amentoflavone (25 mg/kg; p.o.; once a day for 3 consecutive days) shows neuroprotective role in epilepsy via anti-inflammatory effects in mouse^[1].