SEL24-B489
CAS No. : 1616359-00-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $304 | In-stock |
| 25mg | $495 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $970 | In-stock |
| 250mg | $1460 | In-stock |
| 500mg | $2100 | In-stock |
| 1g | $2950 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-120758 |
| M.Wt: | 446.14 |
| Formula: | C15H18Br2N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;adjust pH to 2 with HCl) |
SEL24-B489 is a potent, type I, orally active, dual PIM and FLT3-ITD inhibitor, with Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively[1].
IC50 & Target: Kd: 2 nM (PIM1), 2 nM (PIM2), 3 nM (PIM3)[1].
In Vitro: In MOLM-13 and to a lesser extent in MV4-11 cells, a dose-dependent disruption of cell cycle with especially pronounced depletion of the S phase after treatment with SEL24-B489, accompanied by PARP cleavage and apoptosis was observed[1].
SEL24-B489 causes a profound inhibition of S6 (S235/236), but has little effect on PI3K/mTOR signaling[1].
SEL24-B489 inhibits STAT5 (Ser726) and reduced expression of MCL1, whereas none of the selective inhibitors altered c-MYC abundance or induced PARP cleavage[1].
In Vivo: SEL24-B489 (25-100 mg/kg, orally) exhibited activity in AML in vivo models[1].
SEL24-B489 induces apoptosis of DLBCL cell lines in low/sub-micromolar concentrations and exhibits activity in a xenograft model[2].
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