PF-06726304
CAS No. : 1616287-82-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $43 | In-stock |
| 5mg | $92 | In-stock |
| 10mg | $156 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $660 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-103682 |
| M.Wt: | 446.33 |
| Formula: | C22H21Cl2N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 15 mg/mL |
PF-06726304 is a potent and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 with Kis of 0.7 and 3.0 nM, respectively. PF-06726304 displays robust antitumor growth activity[1].
IC50 & Target: Ki: 0.7 nM (EZH2)[1]
In Vitro: PF-06726304 (Compound 31) inhibits H3K27me3 in Karpas-422 with an IC50 of 15 nM[1].
PF-06726304 inhibits the proliferation of Karpas-422 cells that harbor wild-type EZH2 with an IC50 of 25 nM[1].
In Vivo: PF-06726304 (200 and 300 mg/kg; BID for 20 days) inhibits tumor growth and induces robust modulation of downstream biomarkers in a subcutaneous Karpas-422 xenograft model[1].
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