Cyclo(-RGDfK)
CAS No. : 161552-03-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $102 | In-stock |
| 10mg | $158 | In-stock |
| 25mg | $264 | In-stock |
| 50mg | $367 | In-stock |
| 100mg | $515 | In-stock |
| 250mg | $1287 | In-stock |
| 1g | $4119 | In-stock |
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| Cat. No. : | HY-P0023 |
| M.Wt: | 603.67 |
| Formula: | C27H41N9O7 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 83.33 mg/mL (ultrasonic) |
Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[1][2]. IC50 & Target:IC50: 0.94 nM (αvβ3 integrin)[1]. In Vitro:Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [66Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].
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