BAY 61-3606 (hydrochloride)
CAS No. : 1615197-10-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $165 | In-stock |
| 10mg | $280 | In-stock |
| 25mg | $550 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-76474A |
| M.Wt: | 426.86 |
| Formula: | C20H19ClN6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 160°C) |
BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
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