NITD-916
CAS No. : 1614262-83-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $400 | In-stock |
| 5mg | $965 | In-stock |
| 10mg | $1340 | In-stock |
| 25mg | $1920 | In-stock |
| 50mg | $2350 | In-stock |
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| Cat. No. : | HY-122643 |
| M.Wt: | 311.42 |
| Formula: | C20H25NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 17.5 mg/mL (ultrasonic;warming;heat to 60°C) |
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects[1][2].
IC50 & Target:IC50: 570 nM (InhA)[1]
In Vitro:NITD-916 inhibits Mycobacterium tuberculosis (Mtb) with a MIC50 of 50 nM. The MIC activity of NITD-916 against the MDR-Mtb strains ranged from 0.04 to 0.16 μM[1].
In Vivo:NITD-916 (100 mg/kg; p.o.; daily ; 1 month) shows dose-dependent in vivo efficacy in the lungs of infected mice[1].
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