m-PEG5-CH2COOH
CAS No. : 16142-03-3
| Size | Price | Stock |
|---|---|---|
| 100mg | $39 | In-stock |
| 250mg | $68 | In-stock |
| 1g | $135 | In-stock |
| 5g | $674 | In-stock |
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| 50 g | Get quote | |
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| Cat. No. : | HY-120537 |
| M.Wt: | 310.34 |
| Formula: | C13H26O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
m-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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