Pozanicline
CAS No. : 161417-03-4
(Synonyms: ABT-089)
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| Cat. No. : | HY-14565 |
| M.Wt: | 192.26 |
| Formula: | C11H16N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1]. IC50 & Target: Ki: 16 nM (α4β2* nAChR)[1]
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