Pozanicline (dihydrochloride)
CAS No. : 161416-61-1
(Synonyms: ABT-089 (dihydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $460 | In-stock |
| 50mg | $780 | In-stock |
| 100mg | $1250 | In-stock |
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| Cat. No. : | HY-110160 |
| M.Wt: | 265.18 |
| Formula: | C11H18Cl2N2O |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2].
In Vitro: Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC50 of 0.11 μM[2].
Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes[3].
In Vivo: Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning[3].
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