Z-VAD-FMK
CAS No. : 161401-82-7
(Synonyms: Z-VAD(OH)-FMK)
| Size | Price | Stock |
|---|---|---|
| 1mg | $147 | In-stock |
| 5mg | $310 | In-stock |
| 10mg | $527 | In-stock |
| 25mg | $880 | In-stock |
| 50mg | $1320 | In-stock |
| 100mg | $1980 | In-stock |
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| Cat. No. : | HY-16658B |
| M.Wt: | 453.46 |
| Formula: | C21H28FN3O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis[1][2][3][4][5][6][7].
In Vitro:Z-VAD-FMK (100 μM, 8 h) can induce both autophagy and necrosis in J774A.1 macrophages, indicating that it can trigger non-apoptotic cell death pathways[2].
Z-VAD-FMK (20 μM, 48 h) significantly improves the cryotolerance of Bovine in vitro produced blastocysts by inhibiting apoptosis, and improves the survival and development of embryos after thawing[3].
Z-VAD-FMK (20 μM, 48 h) directly inhibits caspase-3 activation, demonstrating that it improves the cryotolerance of bovine blastocysts by blocking the apoptosis pathway[3].
Z-VAD-FMK (0-100 μM, 72 h) dose-dependently inhibits T cell proliferation mediated through the co-stimulation with anti-CD3 and anti-CD28[4].
Z-VAD-FMK (50-100 μM, 16 h) significantly inhibits FasL-induced T cell apoptosis and caspase-8/caspase-3 treatment[4].
Z-VAD-FMK (25-100 μM, 6-24 h) can deplete and activate GSH in anti-CD3 antibody-pretreated peripheral blood mononuclear cells (PBMCs) following prolonged incubation[5].
Z-VAD-FMK (25-100 μM, 6-24 h) significantly increases ROS levels in primary T cells[5].
In Vivo:Z-VAD-FMK (3 mg/kg, i.p., once every other day, for 3 months) can reduce inflammation and mucus secretion in mice induced by cigarette smoke[6].
Z-VAD-FMK (50 μmol/L (0.3 mL), i.p., 30 mins before modeling) significantly reduces severe acute pancreatitis (SAP)-induced lung tissue pathological damage in a SAP model in rats[7].
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