ARN-3236
CAS No. : 1613710-01-2
| Size | Price | Stock |
|---|---|---|
| 2mg | $110 | In-stock |
| 5mg | $126 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $340 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $690 | In-stock |
| 200mg | $990 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-120856 |
| M.Wt: | 336.41 |
| Formula: | C19H16N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity[1][2].
IC50 & Target: IC50: < 1 nM (SIK2)[1][2].
In Vitro: ARN-3236 inhibits SIK2 activity with an IC50 <1 nM[2].
ARN-3236 inhibits cell growth and increases NSC 125973 sensitivity in ovarian cancer cells[2].
In Vivo: ARN-3236 (60 mg/kg, orally) sensitizes ovarian cancer to NSC 125973 in vivo[2].
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- Cat. No.:
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